Mesothelioma Cancer

What is Mesothelioma Cancer

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Definition of malignant mesothelioma: A rare type of cancer in which malignant cells are found in the sac lining the chest or abdomen. Exposure to airborne asbestos particles increases one's risk of developing malignant mesothelioma.

What is Cancer?

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Cancer cells are very similar to cells of the organism from which they originated and have similar (but not identical) DNA and RNA. This is the reason why they are not very often detected by the immune system, in particular if it is weakened. Cancer cells usually have an increased ability to divide rapidly and their number of divisions is not limited by telomeres on DNA (a counter system to limit number of divisions to 40-60). This can lead to the formation of large masses of tissue and in turn may lead to disruption of bodily functions due to destruction of organs or vital structures.

Mesothelioma Diagnosis

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Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient's medical history and a complete physical examination may be performed, including x-rays of the chest or abdomen and lung function tests. A CT (or CAT) scan or an MRI may also be useful. A biopsy is often used to confirm a diagnosis of mesothelioma. Mesothelioma is described as localized if the cancer is found only on the membrane surface where it originated. It is classified as advanced if the mesothelioma has spread beyond the original membrane surface to other parts of the body, such as the lymph nodes, lungs, chest wall, or abdominal organs.

Symptoms of Mesothelioma

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Shortness of breath and pain in the chest due to an accumulation of fluid in the pleura are often symptoms of pleural mesothelioma. Symptoms of peritoneal mesothelioma include weight loss and abdominal pain and swelling due to a buildup of fluid in the abdomen. Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms of mesothelioma may include pain, trouble swallowing, or swelling of the neck or face.

Mesothelioma Treatments and Therapies

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Standard treatment for all but localized mesothelioma is generally not curative. Surgery and radiotherapy have a limited role in highly selected mesothelioma patients and chemotherapy is the only potential treatment option for the majority of people diagnosed with mesothelioma. Sometimes, these mesothelioma therapies are combined. Despite activity of some chemotherapy, the results are still modest, with a median survival of approximately one year. For individual patients, treatment for mesothelioma depends on the location of the cancer, the stage of the disease, and the patient's age and general health. The only FDA approved chemotherapy for malignant pleural mesothelioma (in combination with cisplatin) is pemetrexed (Alimta). In the key clinical trial that led to its approval for mesothelioma, Alimta was combined with another chemotherapy drug (cisplatin) and compared with cisplatin alone. The median survival for the patients who received both chemotherapy drugs was 12.1 months versus 9.3 months for mesothelioma patients who only received cisplatin.

Mesothelioma Cancer Risk

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Working with asbestos is the major risk factor for mesothelioma cancer. A history of asbestos exposure at work is reported in about 70 percent to 80 percent of all cases. However, mesothelioma cancer has been reported in some individuals without any known exposure to asbestos. Asbestos is the name of a group of minerals that occur naturally as masses of strong, flexible fibers that can be separated into thin threads and woven. Asbestos has been widely used in many industrial products, including cement, brake linings, roof shingles, flooring products, textiles, and insulation. If tiny asbestos particles float in the air, especially during the manufacturing process, they may be inhaled or swallowed, and can cause serious health problems. In addition to mesothelioma, exposure to asbestos increases the risk of lung cancer, asbestosis (a noncancerous, chronic lung ailment), and other cancers, such as those of the larynx and kidney.Smoking does not appear to increase the risk of mesothelioma cancer. However, the combination of smoking and asbestos exposure significantly increases a person's risk of developing cancer of the air passageways in the lung.

Mesothelioma Progonosis and Survival

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In general the prognosis of mesothelioma is poor and most studies report median survival of less than a year. However, there are long term mesothelioma survivors (both pleural and peritoneal survivors) who have survived more than 10 years. In fact, in one mesothelioma study, doctors writing about the prognosis of mesothelioma explained that long-term mesothelioma survivors do exist and their prognosis may be independent of the treatment or therapies pursued.3 If this is true, it would suggest that mesothelioma prognosis and survival may be more dependent on individual differences among patients (and perhaps the non-conventional therapies they use) and less dependent upon conventional mesothelioma treatments.

Mechanisms responsible for Cancer development

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Factors which produce cancer cells are: radiation (such as X-rays, nuclear, microwaves, cosmic, ultrasound, etc.), toxic cell environment, chemicals in the air, water and food, bacteria, viruses and fungi. Factors which suppress immune functions are the same factors as above plus poor diet, stress, lack of proper exercise and lack of sufficient rest and sleep.

Precursors of Cancer and Cancer Prevention

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A weak or non-functioning immune system, poor health, an unhealthy environment and advanced age (over 80) can contribute to cancer. In the majority of people cancer can be prevented with proper lifestyle which consists of a low-entropy diet, exercise, sleep, stress reduction, etc. In most cases cancer develops slowly over many years. With a positive change of lifestyle and healthy environment this trend can be reversed in the majority of cases (probably in 90% -> 95%) - the cancer will shrink and eventually disappear.

New Research in Cancer Treatment

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Genetically engineered bacteria and virusesSome new promising research uses genetically engineered bacteria and viruses to infect and destroy cancer cells. This could be useful when cancer is already advanced and there are large masses of cancer cells. The potential drawback of these methods is the generation of large amounts of toxins from dying cancer cells, which in turn can suppress the immune system or even kill the patient.Also bacteria and viruses very often mutate which in turn can lead to infection and attack on healthy, non-cancerous cells.Anti-cancer vaccinesAnti-cancer vaccines or even custom-made anti-cancer vaccines for a particular patient and cancer type are also a very promising line of research. By providing fragments of cancer cells to the immune system, one can potentially get the immune system response to destroy live cancer cells.Cancer markersAnother promising line of research is related to chemical substances which could be used to mark cancer cells. This in turn will allow easier recognition of these cells by the immune system.Cancer growth retarders / inhibitorsThis line of research is related to the use of chemical substances which could retard / inhibit the growth of cancer cells. An interesting research topics are the substances blocking activity of telomerase, the enzyme responsible for the management/elongation of telomeres.Telomerase is found in high concentrations in 80% of tumors and allows tumor cells to gain "immortality" by removing restrictions on the number of cell divisions. This enzyme may also be useful in extending the lifespan of healthy cells and in turn extend the lifespan of the organism (cancer cells and their growth may hold much valuable information about fountain of youth and immortality).All the above mentioned methods show some promise.However these methods by themselves do not provide reliable cancer treatment. It is possible that some of them in conjunction with the non-traditional treatment of cancer (listed below) will become the standard cancer treatment, in the 21st or 22nd century

"World Cancer Report" by Who

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WHO (World Health Organization, division of UN) estimates that only 4% of all cancers are inherited /genetic and that the majority of cancers are preventable ("World Cancer Report", IARC Press, Lyon 2003). According to this report, various cancers are strongly linked to lifestyle and the environment.It lists many of these factors and carcinogens. Cancer world maps shown in the report illustrate that the majority of cancers are in developed countries which indicates again a strong link between cancer, lifestyle, diet and environment. This statistical data is very consistent with the cancer model outlined in this paper."World Cancer Report" by WHO